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If it is started within 48 hours of when the rash first appears. How to take the drug based on the reason it is prescribed. Once a day, every day. If you take it more than 24 hours after the start of symptoms. Valtrex is most effective if it is started within 48 hours of when the rash first appears. There are no studies that show how well Valaciclovir will work if you take it more than 24 hours after the start of symptoms. Valaciclovir is most effective when taken within 24 hours of the start of signs or symptoms. It is not known if Valtrex prevents the spread of the herpes virus family. Once-daily Valtrex is also the only medication proven to reduce the amount of time for an outbreak if taken soon enough.
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