Nexium capsules should be taken at least one hour before meals and at the same time every day. Taking Esomeprazole? Nexium decreases the amount of acid backing up into the esophagus and causing reflux symptoms. Esomeprazole works best if taken on an empty stomach at least one hour before a meal. Esomeprazole is available with a doctor's prescription and is commonly called by its brand name, Nexium.
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