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Do not take more or less of it or take it more often than prescribed by your doctor. Isotretinoin is used to treat severe acne that is resistant to more conservative treatments such as creams, drying agents, and topical or oral antibiotics. Accutane is a systemic medication which affects most parts of the body. One should follow an acne care regime prescribed by a doctor. Exactly how Accutane works, we would love to hear from you. When acne is severe, the symptoms will be very obvious to the individual suffering from it. You is greater than the risk of side effects.