If you experience bothersome side effects, stop taking Microzide and contact your doctor or local pharmacist. This medicine should not be taken within four hours of colestipol or cholestyramine, as these medicines may reduce the absorption of hydrochlorothiazide from the gut. The removal of salts from the blood, it also causes more water to be drawn out of the blood and into the urine. This medicine is therefore not recommended for people taking lithium. Although there are no adequate and well-controlled studies using hydrochlorothiazide in pregnancy, thiazide diuretics may cause an increased risk of congenital defects.
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