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Prednisone, are commonly used to suppress the immune system. Since prednisone is used in so many conditions, only the most common or established uses are mentioned here. If you have any of these conditions, you may need a dose adjustment or special tests to safely take Prednisolone. Your immune system, making it easier for you to get an infection. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired.